The experiment was conducted to study the effect of different salinity levels on the growth and survival of Nile tilapia (Oreochromis nhloticus) in cemented tanks having dimensions 2.896x0.762x0.914 meters (length x width x depth) or 2.018 cubic meters for three months (thirteen weeks). There were four treatments and a control; each having two replicate and 15 fish was stocked in each replicate. At the time of stocking, the average body weight of Nile tilapia (Oreochromis nhloticus) was 23.0±3.51 and 23.2±3.78, 22.2±2.98 and 22.8±416, 22.9±3.69 and 22.9±3.09, 24.7±4.50 and 23.1±4.98, 24.3±4.51 and 25.0±5.36 (g) in control, treatment 1, treatment 2, treatment 3 arid treatment 4 (Tank I and Tank2 of each treatment), respectively. Fish were regularly fed at the rate of 4% of its body weight on daily basis and growth parameters viz., increase in body weight and total length of fish were monitored on weekly basis. After recording data, fishes were released back into their respective tank. At the end of experiment the average body weight of Nile tilapia (Oreochromis nhloticus) was 43.2±4.87 and 38.7±5.47, 47.4±5.24 and 44.6±7.24, 48.8±7.33 and 44.4±6.54, 48.4±6.80 and 44.4±8.68, and 48.1±7.87 and 50.4±9.67 (g) in control, treatment 1, treatment 2, treatment 3 and treatment 4 (Tankl and Tank2), respectively. Physico-chemical characteristics viz., water temperature, dissolved oxygen (DO), pH electrical conductivity (EC) were also monitored on the daily basis. Better growth performance in terms a average weight gain (g) and average length gain (cm) was seen in treatment containing highest salinity level viz. 4000 ppm. Better food conversion ratio (FCR) was found in 1600 ppm salinity level and increases with increased salinity level. Feed intake was kept lowest at lowest level of salinity i.e. 800 ppm which linearly increases with increasing levels of salinity. It was noted that at high salinity the growth of Nile tilapia showed improved growth potential. This might be due to better ionic balance and improved acid-base balance in the body which leads to better performance. Physico-chemical characteristics viz., temperature, conductivity and pH showed positive and significant correlation but DO showed significant negative correlation on body weight and length, but correlation among both response parameters (weight with length) was significantly positive.